Not really.
I have Exchange, AD, FS, SQL, TMG all cluster on VMware ESX across two datacentres.
It can even blow out core switches and keep on trucking.
The staff don't even notice as its seemless.
Web is much easier to sync and sql is pretty easy compared to other services

.
Using VSS and then pushing those up with something like EMC is very easily doable for having quick turn around on backup of a failed box.
Blow up a new vm, hell have a hot stand by image.
Drop the last snapshot onto it, and bang, you are back online in less then 15 minutes.
Kind regards,
Beingaware,
CCNP R&S, Voice, Datacentre, ASA
VCP5-DCV
RHCSA
MCITP 2008/2012
ITILv3
B.Sc
We done with our pissing match?
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